Pharmaceutical Manufacturing
Pharmaceutical powder blending is one of the most strictly regulated mixing processes in any industry. The blend uniformity of the API and excipient formulation directly determines tablet content uniformity - the most critical quality attribute of a solid dosage form. QUICK PROPACK supplies GMP-compliant pharmaceutical mixers built to the highest documentation and material standards.
Recommended mixer
Horizontal ribbon mixer (SS316L, mirror polish, CIP) for most applications
Conical screw mixer for fragile APIs
Vacuum dryer mixer for heat-sensitive APIs mixer (temperature-controlled applications)
API & Excipient Blending
- API blending with excipients - direct compression blends, pre-granulation and post-granulation blending
- Microcrystalline cellulose (MCC) - Avicel PH-101, PH-102, PH-200 blending
- Lactose monohydrate - fast-flo, spray-dried, anhydrous lactose blending
- Mannitol - DC-grade mannitol blending for direct compression
- Croscarmellose sodium (Ac-Di-Sol) - disintegrant incorporation
- Magnesium stearate - lubricant incorporation - critical last-step blending
- Povidone (PVP) - binder incorporation
- HPMC (hydroxypropyl methylcellulose) - matrix former blending
- Colloidal silicon dioxide (Aerosil) - glidant incorporation
- Stearic acid blending - tablet lubricant
- Crospovidone (Polyplasdone) - super-disintegrant blending
- Calcium phosphate dibasic - filler/diluent blending
Dosage Form Applications
- Tablet formulation blending - immediate release, sustained release, enteric-coated
- Capsule fill blending - hard gelatin and HPMC capsule fill formulations
- Effervescent tablet blend - citric acid, sodium bicarbonate, active ingredient blend
- Controlled substance API blending - Schedule I through V narcotics and controlled substances
- Veterinary pharmaceutical powder blending
- OTC pharmaceutical blending - antacids, analgesics, antihistamines
- Herbal and botanical supplement blending - standardized extract blending
Standard specification for pharmaceutical: SS316L full vessel, #7 mirror polish, CIP-ready spray systems, mechanical shaft seals, PLC with 21 CFR Part 11 compliant batch data logging, material test certificates (MTCs) on all product-contact parts. All pharmaceutical configurations are custom order.
